Medications


Regorafenib Oral Tablet

Brands: Stivarga

Uses

For treating cancer.

Instructions

Swallow the medicine without crushing or chewing it.

Keep the medicine in its original container.

Take this medicine after a low-fat meal.

It is very important that you take the medicine at about the same time every day. It will work best if you do this.

Store at room temperature away from heat, light, and moisture. Do not keep in the bathroom.

Keep the desiccant (drying) packet in the bottle and keep the bottle closed tightly.

Discard any unused medicine after 7 weeks.

Avoid grapefruit juice while on this medicine.

This medicine may cause you to become more sensitive to the sun. Use sunscreen or wear protective clothing when you are exposed to the sun.

It is important that you keep taking each dose of this medicine on time even if you are feeling well.

If you forget to take a dose on time, take it as soon as you remember. If you don't remember until the next day, do not take the missed dose. Return to your normal dosing schedule. Do not take 2 doses of this medicine at one time.

Drug interactions can change how medicines work or increase risk for side effects. Tell your health care providers about all medicines taken. Include prescription and over-the-counter medicines, vitamins, and herbal medicines. Speak with your doctor or pharmacist before starting or stopping any medicine.

Talk to your doctor before taking other medicines, including aspirins and ibuprofen containing products. Speak to your doctor about which medicines are safe to use while you are on this medicine.

Do not suddenly stop taking this medicine. Check with your doctor before stopping.

Use effective birth control to avoid pregnancy.

Keep all appointments for medical exams and tests while on this medicine.

Do not take the medicine more than once during 24 hours.

Cautions

Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine.

Some patients on this medicine have developed severe, life-threatening infections. Please speak with your doctor about the risks and benefits of using this medicine.

Some patients taking this medicine have experienced serious side effects. Please speak with your doctor to understand the risks and benefits associated with this medicine.

To avoid a serious skin reaction, avoid exposure to heat or hot water and pressure on elbows, knees and feet. For example, avoid tight clothing, kneeling, or long walks.

This medicine has been associated with a rare but serious skin rash. If you notice any red, peeling or blistered skin, contact your doctor immediately.

This medicine is associated with an increased risk of serious heart problems and heart attack. Please speak with your doctor about the risks and benefits of using this medicine. Contact your doctor immediately if you experience chest pain or difficulty breathing.

This medicine may cause serious bleeding from the stomach or bowels. Stop this medicine and call your doctor immediately if you see any signs of bleeding. Bleeding can cause pain in the stomach, vomiting up liquid that looks like coffee grounds, and red or dark tarry stools.

This medicine is associated with a rare, but serious problem of the liver. Speak to your doctor about the early signs of liver problems and the benefits and risks of using this medicine.

There is an increased risk of bleeding while on this medicine, please tell your doctor or nurse if you notice any excessive bleeding or bruising.

Do not use the medication any more than instructed.

Contact your doctor if you notice a change in the amount or darkening of your urine.

This medicine may reduce your body's ability to fight infections. Avoid contact with people with colds, flu or other infections. Contact your doctor if you develop fever, cough, sore throat, or chills.

Speak with your health care provider before receiving any vaccinations.

Tell the doctor or pharmacist if you are pregnant, planning to be pregnant, or breastfeeding.

Do not breastfeed while on this medicine. You may safely start breastfeeding 2 weeks after stopping treatment.

Do not use this medicine if you are pregnant. If you become pregnant while on this medicine, contact your doctor immediately.

This medicine can cause birth defects. Speak with your doctor about birth control methods that should be used while on this medicine.

This medicine can hurt a new baby in the womb. If you become pregnant while on this medicine, tell your doctor immediately. Your doctor may switch you to a different medicine.

Women must use reliable forms of birth control while taking this medicine and for 2 months after stopping to prevent pregnancy.

Men with a female partner who is of childbearing age must use reliable birth control during sexual activity while taking this medicine and for 2 months after stopping to prevent pregnancy.

Do not take St. John's wort while on this medicine.

Women who are pregnant or in their childbearing years should not touch or handle this medicine. This medicine can be absorbed through the woman's skin and harm the unborn baby.

Call your doctor right away if you notice any unusual bleeding or bruising.

Do not share this medicine with anyone who has not been prescribed this medicine.

Side Effects

The following is a list of some common side effects from this medicine. Please speak with your doctor about what you should do if you experience these or other side effects.

  • decreased appetite
  • diarrhea
  • dry mouth
  • hair loss
  • mouth sores or irritation
  • changes in taste or unpleasant taste
  • weight loss

Call your doctor or get medical help right away if you notice any of these more serious side effects:

  • increased risk of bruising and bleeding
  • bleeding or bruising
  • chest or jaw pain
  • confusion
  • coughing
  • coughing up blood or vomit that looks like coffee grounds
  • fever or chills
  • pain, redness, swelling or blistering on hands, feet or elbows
  • numbness or tingling in hands and feet
  • fast, irregular, or slow heartbeat
  • high blood pressure
  • signs of liver damage (such as yellowing of eye or skin, dark urine, or unusual tiredness)
  • muscle pain
  • red, burning, or itchy skin
  • seizures
  • shortness of breath
  • red, peeling or blistering skin
  • skin tingling, burning or prickly feeling
  • sore throat
  • bloody or dark, tarry stools
  • increased risk of sunburn
  • unusual or unexplained tiredness or weakness
  • urinating less often
  • blood in urine
  • blurring or changes of vision
  • weight gain
  • slow wound healing

A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.

Extra

Please speak with your doctor, nurse, or pharmacist if you have any questions about this medicine.

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IMPORTANT NOTE: This document tells you briefly how to take your medicine, but it does not tell you all there is to know about it. Your doctor or pharmacist may give you other documents about your medicine. Please talk to them if you have any questions. Always follow their advice. There is a more complete description of this medicine available in English. Scan this code on your smartphone or tablet or use the web address below. You can also ask your pharmacist for a printout. If you have any questions, please ask your pharmacist. The display and use of this drug information is subject to Terms of Use. Copyright(c) 2022 First Databank, Inc.


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